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Översättning 'amiodarone' – Ordbok svenska-Engelska Glosbe

Mechanism of Action Amiodarone is a primarily a class III antiarrhythmic. Like other antiarrhythmic drugs of this class, amiodarone works primarily by blocking potassium rectifier currents that are responsible for the repolarization of the heart during phase 3 of the cardiac action potential. Mechanism: The mechanism of action of amiodarone is complex. Although originally classed as one of the prototype class 3 antiarrhythmic drugs that widen action potentials, it has since been found to block other channels, and even β-adrenoceptors.

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Amiodarone was the first agent described in this class. Amiodarone is an antiarrhythmic drug with structural similarities to thyroxine. It exhibits all four of the classic Vaughan Williams mechanisms of action, namely sodium and potassium channel blockade, a mild antisympathetic action and some calcium channel blockade, but it is usually classified as a Class III antiarrhythmic drug (see Table 1).

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Amiodarone may cause your arrhythmia (irregular heart rhythm) to worsen or may cause you to develop new arrhythmias. Tell your doctor if you have ever been  Mechanisms of Action: Physiological Effects Amiodarone (AMD) represents a promising new class of antifungal drug, the class III antiarrhythmics (7), and the  Dec 1, 2015 MECHANISM OF ACTION: Amiodarone is categorized as a class III Antiarrhythmic agent and prolongs phase 3 of the cardiac action potential, the  Amiodarone-induced thyroid dysfunction occurs because of both its iodine the epidemiology and mechanism of amiodarone-induced thyroid dysfunction, Antagonism of thyroid hormone action by amiodarone in rat pituitary tumor cells. Mar 19, 2015 •Describe indications of, and mechanism of action for, the various classes of antiarrhythmic Can be used in combination with amiodarone. Mar 3, 2014 Amiodarone is a class III antiarrhythmic, but has a broad-spectrum of antiarrhythmic action exhibiting characteristics of all 4 Vaughn Williams Some proposed mechanisms of pulmonary toxicity include injury of type II&n Oct 28, 2014 This means that, Phase 0 of the Action Potential (which is the fast Because of the above mechanism, slow L-Type Calcium Channels are also  Nov 26, 2017 Its mode of action is complex, with effects thought to be on multiple ion Arguably, the most likely mechanism whereby amiodarone increases  Pharmacology Nursing Mnemonics & Tips - Nurseslabs. It is the goal of these nursing mnemonics to provide an easy quick-guide to simplify the concepts of  Oct 2, 2017 Mechanisms of action of nifurtimox and benznidazole. target lanosterol C14 demethylase, and amiodarone and dronedarone partially inhibit  IV. Mechanism. Class IA Antiarrhythmic.

As a result amiodarone increases the duration of the action potential as well as the effective refractory period for cardiac cells (myocytes). Amiodarone potentiates the action of warfarin by inhibiting the clearance of both (S) and (R) warfarin. Individuals taking both of these medications should have their warfarin doses adjusted based on their dosing of amiodarone, and have their anticoagulation status (measured as prothrombin time (PT) and international normalized ratio (INR)) measured more frequently. Se hela listan på study.com Tissue accumulation of amiodarone and its active metabolite (desethylamiodarone) may modulate the chronic effects, causing variable suppression of excitability and conductivity of the heart through the direct effects of the compounds retained at the sites of action. Amiodarone and desethylamiodarone could antagonize triiodothyronine (T3) action on the heart at cellular or subcellular levels, leading to phenotypic resemblance of long-term amiodarone treatment and hypothyroidism. Se hela listan på drugs.com A specific mechanism of action is responsible for amiodarone's effects within the body.
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Like other antiarrhythmic drugs of this class, amiodarone works primarily by blocking potassium rectifier currents that are responsible for the repolarization of the heart during phase 3 of the cardiac action potential. Amiodarone is an iodinated benzofuran derivative that was synthesized and tested as an antianginal agent in the 1960s but was later discovered to have antiarrhythmic properties. Amiodarone is widely prescribed, largely due to its efficacy in the management of both supraventricular and ventricular arrhythmias.
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Mechanism of antiarrhythmic action-- primarily activated sodium channel blockade which results in: Amiodarone (Cordarone) (Class I and III Channel Blocker). Ivermectin's mechanism of action as an antiparasitic is related to the activation of Treatment of AML cell lines with a combination of amiodarone and ABT-263  per minute (b.p.m.) at rest], the mechanism of which involves tissue. from the His Continued. i.v.

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i.v. amiodarone is not recommended for pre-excited AF. III action after intranasal administration, conversion rates from SVT to.

In the rare situation that IV access is not immediately available, atropine can be given intraarterially or endotracheally. Pharmacologic action. Amiodarone inhibits  Mechanisms of action. Although known antiarrhythmic, amiodarone has characteristics of intravenous (IV) administration, amiodarone also reduces  Sep 30, 2016 In this article, you can read about their mechanism of action, main Class 3 are potassium channel blockers – amiodarone, dronedarone,  The effect of amiodarone, a new antianginal drug, on cardiac muscle.